| ENTRIL 5
FOR CATTLE, PIGS, DOGS and CATS
PRESENTATION:
A ready to use sterile aqueous injectable solution
containing 50 mg/ml enrofloxacin.
USES:
Enrofloxacin is a synthetic, broad spectrum antimicrobial,
bactericidal in action and effective against a wide
range of gram positive and gram negative bacteria
as well as mycoplasmas.
Cattle
Diseases of the respiratory and alimentary tract,
of bacterial or mycoplasmal origin, e.g. pasteurellosis,
mycoplasmosis, coli-bacillosis, coli-septicaemia and
salmonellosis, and secondary bacterial infections
subsequent to viral conditions, e.g. viral pneumonia,
where clinical experience, supported where possible
by sensitivity testing of the causal organism, indicates
enrofloxacin as the drug of choice.
Pigs
Diseases of the respiratory and alimentary tract,
of bacterial or mycoplasmal origin, e.g. pasteurellosis,
actinobacillosis, mycoplasmosis, coli-bacillosis,
coli-septicaemia and salmonellosis, and multifactorial
diseases such as atrophic rhinitis and enzootic pneumonia,
where clinical experience, supported where possible
by sensitivity testing of the causal organism, indicates
enrofloxacin as the drug of choice.
Dogs and Cats
ENTRIL 5 is indicated in the treatment of alimentary,
respiratory, and urogenital tracts, skin, secondary
wound infections, and Otitis externa, where clinical
experience, supported where possible by sensitivity
testing of the causal organism, indicates enrofloxacin
as the drug of choice.
DOSAGE AND ADMINISTRATION:
Cattle
0.5 ml per 10 kg bodyweight (2.5 mg enrofloxacin per
kg bodyweight) daily by subcutaneous injection for
3 days.
For salmonellosis and complicated respiratory disease
this rate may be doubled to 1 ml per 10kg bodyweight
(5 mg enrofloxacin per kg bodyweight) daily by subcutaneous
injection for 5 days.
Not more than 10 ml should be administered at one
subcutaneous injection site.
Pigs
0.5 ml per 10 kg bodyweight (2.5 mg enrofloxacin per
kg bodyweight) daily by subcutaneous injection for
3 days.
For salmonellosis and complicated respiratory disease
this rate may be doubled to 1 ml per 10kg bodyweight
(5 mg enrofloxacin per kg bodyweight) daily by subcutaneous
injection for 5 days.
Not more than 2.5 ml should be administered at one
subcutaneous injection site.
Dogs and Cats
1 ml per 10 kg bodyweight (5 mg enrofloxacin per kg
bodyweight) daily by subcutaneous injection for up
to 5 days.
CONTRA-INDICATIONS, WARNINGS ETC:
For animal treatment only.
KEEP OUT OF THE REACH OF CHILDREN.
Do not exceed the recommended dose.
Only administer by the routes outlined above (under
dosage and administration).
Normal sterile precautions should be taken.
Local tissue reactions may occasionally occur at the
injection site.
Do not use in cattle producing milk for human consumption.
Do not use in dogs less than 1 year of age (or, in
exceptionally large breeds with a longer growth period,
under 18 months of age) as articular cartilage may
be affected during the period of rapid growth.
Not recommended for use in cats less than 8 weeks
of age.
Cats receiving very high doses (20 mg/kg or above)
have shown signs of visual deformities.
WITHDRAWAL PERIODS:
Cattle
Must not be slaughtered for human consumption during
treatment or until 14 days after the last treatment.
Pigs
Must not be slaughtered for human consumption during
treatment or until 10 days after the last treatment.
PHARMACEUTICAL PRECAUTIONS:
Store below 25 degrees Centigrade in a dry place.
Following withdrawal of the first dose, use the product
within 28 days.
Discard unused material.
PACKAGE QUANTITIES: 100 ml
multi-dose vials.
FURTHER INFORMATION:
The pharmacokinetics of enrofloxacin are
such that both oral and parenteral administration
lead to similar serum levels. Enrofloxacin possesses
a high distribution volume. Tissue levels 2-3
times higher than that found in the serum have been
demonstrated in laboratory animals and target species.
Organs in which high levels cab be expected are the
lungs, liver, kidney, bone, and lymphatic system.
Enrofloxacin also distributes into the C.S.F., the
aqueous humour, and the foetus in pregnant animals.
Occasionally skin reactions have been seen after administration
in kennelled greyhounds.
|
